Advise the affected person to read the FDA-authorized affected person labeling (Remedy Information). Inform patients that leaving OPANA Tablets unsecured can pose a deadly threat to others in the house. Advise patients and caregivers that when medicines are now not needed, they ought to be disposed of promptly. Expired, unwanted, or unused OPANA Tablets must be disposed of by flushing the unused medication down the bathroom if a drug take-again possibility isn't readily out there. Instruct patients not to share OPANA with others. To take steps to protect OPANA from theft or misuse. Advise patients how to recognize respiratory depression. To hunt medical attention if respiratory difficulties develop. Inform patients that anaphylaxis, angioedema, and other hypersensitivity reactions have been reported with ingredients contained in OPANA. Inform patients that opioids might trigger a uncommon but probably life-threatening condition ensuing from concomitant administration of serotonergic drugs. Warn patients of the symptoms of serotonin syndrome. To seek medical consideration instantly if signs develop. Inform patients to keep away from taking OPANA while using any drugs that inhibit monoamine oxidase. Inform patients that opioids could cause adrenal insufficiency, a potentially life-threatening situation. Adrenal insufficiency might current with non-specific symptoms and indicators resembling nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. Instruct patients methods to properly take OPANA precisely as prescribed to scale back the danger of life-threatening hostile reactions (e.g., respiratory depression). Advise patients not to regulate the dose of OPANA without consulting with a physician or different healthcare professional. Inform patients that OPANA could cause orthostatic hypotension and syncope. Advise nursing mothers to watch infants for increased sleepiness (more - www.instantfundas.com - than ordinary), breathing difficulties, or limpness. Inform patients that chronic use of opioids may cause lowered fertility. https://remedialpharmacy.com that OPANA may impair the power to carry out doubtlessly hazardous actions resembling driving a car or working heavy equipment. OPANA® is a registered trademark of Endo Worldwide plc or one in all its affiliates. 2019 Endo Pharmaceuticals Inc. All rights reserved.