Zaleplon,zolpidem and zopiclone (the Z-drugs) are non-benzodiazepine hypnotics. They were developed with the aim of overcoming some of the adverse events associated with benzodiazepines - primarily dependence and withdrawal.

Zolpidem (10 mg/day) and zopiclone (7.5 mg/day), administered at night, were compared in a 14-day, double-blind, equivalence trial on 479 chronic primary insomniacs (zolpidem, 231; zopiclone, 248) throughout Japan, with a 1-week follow-up to assess rebound. The primary endpoint was the investigators' rating of global improvement of sleep disorders. A total of 32 patients in the zolpidem group (13.9%) and 45 patients in the zopiclone group (18.1%) withdrew from the study before the end of the treatment. In the zolpidem group, 67.9% (142/209) of patients were rated at least 'moderately improved' versus 61.6% (135/219) with zopiclone, zolpidem being at least as effective as zopiclone (90% confidence interval: -1.7, 14.3). With zolpidem, sleep onset latency improved in significantly more patients (85.8% versus 77.5%) and significantly fewer patients showed aggravated sleep onset latency relative to baseline at follow-up (4.5% versus 15.4%). Significantly fewer patients receiving zolpidem experienced drug-related adverse events (31.3% versus 45.3%), with bitter taste representing 5.8% (six of 104) of such complaints with zolpidem compared with 39.9% (69/173) with zopiclone. In conclusion, zolpidem was at least as effective as zopiclone, showed significantly less rebound on discontinuation and was better tolerated.

Zolpidem is a drug that comes under the brand name Ambien. It is used for the prescription of short-term treatment of insomnia. Insomnia means a problem in sleeping for adults. It directs your brain to give better sleep.
Method of use
It comes as a tablet and you can take it before going to bed at the night. This medicine comes as a sublingual tablet to place under the tongue, and as an oral spray to be sprayed in the mouth over the tongue. Don’t consume these medicines more than a single time a day immediately before bedtime. Zolpidem works faster if you consume it without the meal or immediately after the meal, and never take this medicine without a doctor’s prescription, or without professionals advice.
Dosage of zolpidem
Go to your doctor to know your dose according to your medical condition and gender. Do not consume this medicine more than a single time immediately before going to bed. Consume only under the guidance of the doctor and according to prescription.
Side effects of zolpidem.
The medication causes you to sleep all day. Serious side effects are such as mental depression, behavior changes, confusion, aggression, thoughts of suicide, etc.
It causes serious sleep behaviors. Some people after taking this medicine start doing all their works such as prepare their food, drive their car and do all their works and activities while not fully awake after they wake up they don’t remember what they had done. If you are facing any such side effects stop taking medicines and instantly go to your doctor.
Zopiclone
Zopiclone is a drug that is also used to treat sleeping problems such as insomnia. It is sold under the brand name Imovane. Its trade names are imovane, zimovane, dopareel, etc. This medicine is prescribed by the doctor to give you better sleep.
Methods of use
Take this medicine according to the direction of the doctor. It comes as a tablet. Take it by mouth before going to bed.
Dosage of zopiclone
Consume this medicine only after prescribed by the doctor and under the guidance of the doctor. A doctor gives you doses according to your medical health and condition. Consume the medicine instant before going to bed. This medicine is prescribed for no longer than a month longer than the prescription, longer than the prescription may cause addiction.
Side effects of zopiclone
When you start taking this drug then the body will take time to adjust and it will cause some common side effects such as dizziness, bitter taste, dry mouth, and headache that can happen in the first few days. If these effects continue then inform your doctor and take a better suggestion. There are some serious side effects are such as irregular or rapid heartbeat, skin rash, changes in vision, slurred speech, severe drowsiness, loss of memory, incoordination, confusion, depression, irritability, or other behavioral changes. If you are getting any such side effects then stop using medicine and instantly go to your doctor for better suggestions.
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