The collagen gene of type III has a unique arrangement of head-to–head orientation within the transcriptional unit, that results in a bifunctional promoter. The proximal promoter is in close proximity to COL4A5 and COL4A6 and regulates the expression of specific cell types in the cell and in vitro however it does not control expression in transgenic mice. It is not clear if the internal promoter plays any part in the regulation or production of collagen.

This promoter has been studied in mouse and chick cells, but is not as active as the one from mouse or human. In a transgenic research study, it was discovered to be highly active in the fibroblastic NIH 3T3 cells. Contrary to this, the chick type III collagen promoter requires sequences that range between 798 and 580. Additionally, the a1(I)-collagen promoter fragment was not active in C2C12 or F9 cells.

The pF-239/+44 sequence has a highly conserved sequence across species and has been found to be inactive in mouse and human skin fibroblasts. It is interesting to note that the pF-239/+41 promoter is a possible CCAATT-box that is located near transcription start site. In addition the promoter was located in mouse and human collagen type III genes, however the functional role of the CCAATT box has not been elucidated.

The promoters of human and mouse type III collagen genes are highly homologous and conserved. The human and mouse type III collagen genes have similar cis-acting sequences. The chick type III promoter has two elements that are bound to an AP-1-like and a new factor. Three regions are necessary for the expression of both kinds of collagen. For example the chick collagen promoter needs a cis-acting sequence between -798 and 580.

The CCAAATT box is not present in the collagen promoter of type IV. It also has evolutionarily conserved elements, but it is inactive in mousefibroblasts. It also has the CCAATT box that can be activated, and is located closer to the transcription start site than usual 레니스나. While the CCAATT box is present in both human and mouse types of type III collagen genes however, the function of the CCAAAC box remains largely unknown.

The first intron contains the chromosomal enhancer for type II collagen. Intron 23 is the alternative promoter for type II collagen. The internal promoter for type II collagen is located in the chick with two introns A2(I) Chondrocytes. The type I intron of a chondrocyte is the chromosomal DNA sequence of this gene. The SjP40 has a direct effect on collagen, which results in the development of the muscles of the skeletal.

The a1(I-collagen promoter measures 2.3 kb in length. The OG2-Cre promoter measures 1.3 kb. The a1(I),-collage promoter contains an cis-acting element that acts as the transcription factor. It is a molecular transcriptionally active. The OC2 promoter is a monomer that is highly conserved in both cell lines.