Several academic groups, including various universities and hospitals, are contributing significantly towards the development of these novel therapeutics against various oncological disorders. Eminent researchers and experienced scientists, affiliated to such renowned research / academic institutes, are generally chosen to lead clinical investigations for specific disease areas. Various principal investigators or sub-investigators or study directors of clinical trials, considering them to be the key opinion leaders (KOLs), who are actively involved in the study of TIL-based trials worldwide.

TIL-based therapies are currently being developed by various research groups at (in alphabetical order) Duke University Medical Center, H. Lee Moffitt Cancer Center and Research Institute, Hillman Cancer Center, Keio University School of Medicine, Lausanne University Hospital, MD Anderson Cancer Center, Nantes University Hospital, National Cancer Institute, Ohio State University Comprehensive Cancer Center and Roswell Park Cancer Institute.

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In an interview with the Chief Operating Officer of a T-Cell immunotherapy-based company, stated that, “We have witnessed substantial success and there is a lot of clinically significant data, validating the potential of TIL-based based therapies. However, we intend to continue to explore novel approaches to cater to the need for effective therapies across additional disease indications. A number of companies, having realized the opportunity in this field, are making active attempts to develop enabling technologies in order to support the growth of this market.”

Companies / institutions that have in-house manufacturing capabilities and contact manufacturers for different types of immunotherapies. In addition, various companies use their in-house manufacturing facilities (which are typically dedicated to the production of proprietary products) for contract manufacturing purposes as well.

Example of such companies include apceth Biopharma, China Bio-Med Regeneration Technology (CRMI), Cook Myosite, FUJIFILM Cellular Dynamics, GC Cell, MaSTherCell, MolMed, Oxford BioMedica and Pharmicell.

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