What Is Brown Fat? Can It Help Your Body Lose Weight? - Truths

At a Look Researchers acquired key insights into brown fat's effects on the body's metabolic process. Metabolic process involves the chemical responses that break down the food we consume into sugars, fats, and amino acids.

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Metabolic process can be impacted by lots of factors, such as diet plan, genes, the environment, and everyday activity. Brown fat breaks down blood sugar Geeks Health level (glucose) and fat particles to produce heat and assistance maintain body temperature level. Cold temperatures activate brown fat, which leads to various metabolic modifications in the body. Most of our fat, however, is white fat, which stores additional energy.

Researchers have actually been working to harness brown fat's activity in order to treat obesity, diabetes, and other metabolic disorders. To acquire a deeper understanding of how brown fat impacts metabolism, a group led by Dr. Shingo Kajimura at the University of California, San Francisco, carefully examined blood levels of glucose, fats, and amino acids before and after activation of brown fat in 33 healthy young men (typical age about 23 years of ages).

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Results were published online on August 21, 2019, in Nature. Based on measurements taken at normal room temperature, the team classified 17 of the men as having high brown fat activity and 16 as low activity. They then exposed the guys to a temperature level cold adequate to activate their brown fat (but not low enough to trigger them to shiver) for two hours.

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This change wasn't seen in the males with low brown fat activity. Experiments in overweight mice validated that cold exposure lowered BCAAs in rodents with brown fat, too.

The researchers carried out a series of experiments to even more investigate the relationship between brown fat and BCAAs. They found that brown fat produces a protein called SLC25A44 upon cold direct exposure. SLC25A44 brings BCAAs into mitochondria, the cell's energy compartment, where they are used to produce energy and generate heat.

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"The findings recommend that boosting SLC25A44 activity, therefore boosting BCAA utilization, may be an appealing strategy for removing excess BCAAs from the bloodstream and potentially treating conditions such as weight problems and diabetes," Kajimura says. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, Mc, Garrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, Mc, Manus MT, Saito M, Soga T, Kajimura S.

2019 Aug 21. Structure; American Diabetes Association; Japan Firm for Medical Research and Development; Japan Society for the Promo of Science.