Peyton started the first game of his NFL career against the Miami dolphins. Colts finally defeat, Peyton out professional league first touchdown, on the pass code number at 3739 yards broke records rookie pass code number, but at the same time manning out 28 times steals, is also a league record. In the 2000 season, Peyton Manning's passing reached a high level, and peyton was the first NFL pass Madden 18 Coins.

In the 2001 season, in the third game of the New England patriots, peyton first met the arch-enemy Tom brady and the first in his career. In the 2006 season, the colts played the giants and peyton first came to play with his younger brother eli. This is the first time the NFL has played a quarterback against a brother, known as the "manning bowl".