Longevity & Anti-senescence Therapy Market: Introduction
Aging is characterized by a progression in losing of physiological integrity and function over time. Aging epigenetics refers to changes in gene expression that naturally occur during an organismal lifespan without altering the DNA sequence. Chromatin epigenetics is regulated by several enzymes, which collectively give rise to modifications in DNA methylation and histone methylation/acetylation processes. During aging, chromatin appears to be in a more active state, with an overall decrease in DNA methylation, thus leading to more relaxed global gene expression. Senescent cells are linked with many age-related diseases such as neurodegenerative diseases (Alzheimer’s and Parkinson’s disease; AD and PD, respectively), cataract, glaucoma, cardiovascular diseases (CVD, atherosclerosis, and hypertension), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), diabetes type II, sarcopenia, osteoarthritis, osteoporosis, and certain types of tumors. The development of science and medicine has contributed to the increase in human lifespan. However, with increase in life expectancy, an increase in incidence of age-related diseases has been observed. Therefore, it is crucial to find an approach to prevent or delay ageing and the onset of age-related diseases. The only non-genetic approach that can extend longevity is dietary/calorie restriction (DR/CR). This intervention involves a 20% to 40% reduction in calorie intake without causing malnutrition and has been shown to be effective in several species including yeast, fruit flies, nematodes, rats, dogs, and even primates.
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Key Drivers of Global Longevity & Anti-senescence Therapy Market
Increase in Geriatric Population Worldwide
The world’s geriatric population continues to grow at an unprecedented rate. Today, 8.5% of people worldwide (617 million) are aged 65 and over. According to a new report – ‘An Aging World: 2015’, the percentage is projected to jump to nearly 17% of the world’s population by 2050 (1.6 billion). According to the National Institutes of Health, America’s 65-and-over population is projected to nearly double over the next three decades, from 48 million to 88 million by 2050. The global population of the people aged 80 and older is expected to more than triple between 2015 and 2050, growing from 126.5 million to 446.6 million. The population aged 80 and above in some countries in Asia and Latin America is predicted to quadruple by 2050.
Rise in Awareness of Antiaging Products among Generation Y and Later Generations
Anti-wrinkle products are gaining traction as they have formulation well suited to slower the aging process. Major causes of wrinkles include the lack of essential nutrients in the body, exposure to UV light and pollution for higher duration, smoking, dehydration, and drugs, along with other genetic factors. Greater aging anxiety and higher importance of appearance were related to greater likelihood of purchasing anti-aging products.
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North America to Hold Major Share of Global Longevity & Anti-senescence Therapy Market
• North America is expected to hold major share of the global longevity & anti-senescence therapy market during the forecast period. The market in North America is estimated to expand at a rapid pace in the near future, primarily, due to structured reimbursement policies, increase in prevalence of obesity & cardiovascular diseases, developed health care infrastructure, and continuous research activities in developing advanced technologies in North America.
• The longevity & anti-senescence therapy market in Asia Pacific is projected to expand at a rapid pace during the forecast period. This can be attributed to growing trend of preventive health care measures in North America.
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Key Players Operating in Global Market
The global longevity & anti-senescence therapy market is highly concentrated, due to strong presence of a few key players. Several manufacturers hold major share in the market in their respective regions. Leading players operating in the global longevity & anti-senescence therapy market are:
• Acorda Therapeutics
• Calico Life Sciences
• Human Longevity Inc.
• Insilico Medicine
• Oisin Biotechnology
• Proteostasis Therapeutics Inc.
• Recursion Pharmaceuticals
• Restorbio
• Senex Biotechnology
• Senolytic Therapeutics
• Sierra Sciences LLC