Following the introduction of phenylbutazone, there was a proliferation of NSAIDS for the treatment of both osteoarthritis and rheumatoid arthritis. They are still used today and are effective for relieving pain and inflammation.However, they also have potential side effects including the elevation of cardiovascular risk leading to stroke and heart attack, hypertension, kidney malfunction, and gastrointestinal ulceration. Nonetheless, they are helpful in alleviating arthritis symptoms.
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Less clear is their role for other conditions involving aches and pains and musculoskeletal injury. For example, short term use of NSAIDS for relief of pain due to fractures can be beneficial.The downside is longer term use has been shown in multiple animal studies to slow fracture healing. This deleterious effect on fracture healing has not been seen with the use of acetaminophen.Studies in humans have had mixed conclusions. One study by Giannoudis and colleagues in the Journal of Bone and Joint Surgery found NSAID use to be associated with poor fracture healing. On the other hand, a review of studies carried out by Dodwell and associates in Calcified Tissue International did not find this to be true.
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