Welcome to
On Feet Nation
COVID-19 Impact on the Global Active Pharmaceutical Ingredients (API) in the Pharmaceuticals Industry
WHO (World Health Organization) has characterized novel coronavirus as a global pandemic on March 11, 2020. This present pandemic has led to an intolerable impact on both the health and pharmaceutical structure which has ultimately created an ultimate issue on patients’ health.
APIs are the effective ingredient present in the medicine, and even small amount of active ingredients known to produce effective result. APIs are either used as single dose or as mixed dose combination in order to produce an effective medicine. However, raw materials are confused with the APIs used for making medicine, but the raw materials are the substances which are used for manufacturing of APIs and the chemical compound used for making the raw material is called as an intermediate. Even more than 10 kinds of intermediate chemical compounds are used for manufacturing of a single API. In order to manufacture API, the manufacturer has to first develop the chemical compound at first which is used for further processing of APIs. These API molecules are formed in large sized reactors. After manufacturing, these APIs are checked for purity and their effectiveness as API market is such a huge market and has a great application in the medical field there is a huge demand of close monitoring of manufacturing process. But due to continuous pandemic of COVID-19 and long term shut down has put an adverse effect on overall drug manufacturing companies. The government of several countries has reported that there is huge scarcity of APIs amid the COVID-19 pandemic. The reason behind that is the barrier across the countries border that has an ultimatum effect over the import and export facilities of medicinal product among others.
As the Indian pharmaceutical industry is largely dependent upon the China for procurement of APIs, as China is the first global leader involved in the manufacturing of low cost APIs. This has been reported that approximately 70% of APIs raw materials are imported from China to India. But the continuous pandemic of COVID-19 and barrier across the borders have a massive effect on export of good from one country to another and has led to the scarcity of APIs in India, the U.S. and the U.K. among other countries. As India is the world’s third largest supplier of low-cost and affordable generic drugs to millions of people all over the world and operates about 250 the U.S. FDA, the U.K Medicine and Healthcare product Regulatory Agency approved plants. Hence any impact on Indian APIs pharmaceutical industry led to a negative impact on overall global APIs manufacturing plants.
PRICE IMPACT
The Coronavirus disease (COVID-19) pandemic has enormous impact on global pharmaceutical market involving APIs among others. The demand for APIs is on surge across the globe because of increasing prevalence of coronavirus disease (COVID-19) all over the world and demand of effective treatment options.
The COVID-19 pandemic has resulted in an immense increase in cost of drugs due to rising demand of drugs for treatment of several kinds of disease including HIV, cancer, epilepsy, malaria among others.
For instance,
• As per the data provided by the Pharmaceutical Export Promotion Council (PHARMEXCIL), the cost of Penicillin APIs has raised to USD 8.69 per unit in October 2020 from the USD 6.16 per unit in January 2020.
• Moreover the data procured by the APIs manufacturer suggested that there is an increase in about 13 to 18 percent of APIs prices for antibiotic involving Amikacin, Doxycycline, Azithromycin, Dexamethasone Sodium and Ornidazole among others as India imports most of them from China.
• Montelukast sodium (an anti-asthmatic drug) costs USD 705.93 to USD 787.38 per Kg in October 2020 as compared to USD 447.99 to USD 515.87 per Kg before few months.
• The prices of vitamins and penicillin have also attained a lucrative growth due to sudden rise in their prices by 40 to 50 percent as that of the original existing prices.
• India’s drug pricing regulator has also allowed pharmaceutical companies to enhance the prices of essential drugs by 50 percent including Heparin (an anticoagulant) which is in high demand to increasing risk of COVID-19 infection to patients suffering from heart attacks, strokes and lung or pulmonary embolism.
• As per the publication of April 2020, the cost of azithromycin, paracetamol, anti-inflammatory drug nimesulide APIs enhanced up to 60 to 190% during the pandemic of COVID-19. This price hike was due to shut down of China’s APIs production units. The increasing demand of several kinds of drug during COVID-19 pandemic has enhanced the demand of APIs that in turn led to APIs shortage. These shortages have an ultimatum effect on existing APIs prices.
This signifies that price of APIs hiked due to continuous coronavirus outbreak.
IMPACT ON SUPPLY CHAIN
The COVID-19 pandemic has affected many organizations’ business environment; supply availability of various drugs has been hampered due to a large number of issues, including import and export restrictions across the countries, and continuous lockdowns that have forced suppliers to (temporarily) shut down the manufacturing facilities and supply capabilities. China occupies a predominant position in the global APIs market. China has secured a considerable market share of APIs market at global level and it exports about 17.87% of vitamin APIs among others to other countries.
Moreover, this has been reported that European pharmaceutical companies also rely on India for manufacturing of their products and India is largely dependent on China for 70% of APIs.
Since 1990, the U.S. is heavily relied on India and China for manufacturing of pharmaceutical products among others because China provides cheaper ingredients and those are not subjected to that much high regulatory rules and laws.
Moreover this has been projected out that UNICEF procures most of the pharmaceutical products from China and India and few of them from Europe as well. For Vitamin, a capsule containing Retinol UNICEF and CIK depend on same supplier and also procures from Canada.
Moreover, as the market players are totally aware of the loss that they may likely to suffer due to disruption of supply chain, they are continuously monitoring their product supplies and manufacturing capabilities in order to prevent the loss to their overall business.
For instance,
• Teva Pharmaceutical Industries Ltd., manufacturer of Accutane (Isotretinoin capsules) has announced that the company is enacting all appropriate measures in order to ensure the safe supply of their medicines and APIs.
This signifies that COVID-19 is disrupting the supply chain of APIs, it is also restricting the procurement procedure of APIs from different sources among other factors but several initiatives are taken by the manufacturers and government organizations is creating a hope for the improvement of supply chain of APIs.
Read more…
© 2024 Created by PH the vintage.
Powered by
You need to be a member of On Feet Nation to add comments!
Join On Feet Nation