Does Nsp-1 Protein Holds Potential in COVID-19 Treatment?
Researchers are shifting focus on nonstructural protein 1 (Nsp1), also called the SARS-CoV-2 protein, which is found to interact with the intracellular protein production to suppress the translation of mRNA into protein. Companies in the protein drugs market are collaborating with scientists and researchers to target the interaction of Nsp1 with the host’s protein production mechanism to gain important therapeutic touch-points.
Pharma companies in the protein drugs market are focusing on structure-based drug designs. They are increasing their R&D capabilities to develop drugs that interact between Nsp1 and the host’s ribosome to innovate in potential therapeutic strategies.
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Parenteral Administration of Large Molecular Weight Proteins Improves Clinical Outcomes
Protein pharmaceuticals have become one of the fastest growing class of therapeutics used in the treatment of life-threatening diseases. However, oral administration of protein drugs needs to be addressed by manufacturers in order to facilitate the delivery of large molecular weight proteins and peptides. Hence, companies in the protein drugs market are increasing awareness about parenteral delivery of proteins and peptides to ease the administration of large molecular weights.
The pharmaceutical industry is currently facing a drug delivery slump. Hence, manufacturers in the protein drugs market are adopting the artificial intelligence (AI) technology to accelerate pharmaceutical development. AI is eliminating the need of conventional tools in order to predict whether a drug candidate will be efficacious in patients.
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Proprietary Drug Development Technologies Increase Market Recognition of Companies
Medical researchers directly linked with the protein drugs market have made major advancements in drug development technologies. However, traditional drug innovation models can be slow and expensive. Hence, companies such as the Japan-based biotech company PeptiDream is increasing efforts to advance in its proprietary drug development technology to seek right drug compounds for product innovations.
Proprietary drug development technologies are helping manufacturers in the protein drugs market to gain a competitive edge over other market players. These technologies have spurred the rate of innovation in business models, where manufacturers can develop peptides meant for new medical therapies. Pharma companies are making efforts to innovate in small-molecule and large-molecule drugs in order to gain recognition as a drug discovery engine.
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Small Molecule Drugs versus Large Molecule Drugs: Which is better?
Pharma companies in the protein drugs market are using macrocyclic peptides to advance in product innovations. The easy administration of small molecule drugs is being highly publicized by manufacturers. However, these drugs are potentially instable in nature, owing to their small molecules, which penetrate cell membranes, thus creating unwanted side effects.
On the other hand, protein-based therapeutics are large molecule drugs made using living cells. They are not pills such as small molecule drugs but can be injected or infused. These drugs are designed for specific targets; however, there are uncertainties if they reach all required targets. Hence, companies in the protein drugs market are focusing on proprietary technologies for product innovation.
Protein Purification Vital for Innovations in Protein-Polymer Therapeutics
Companies are deploying computational techniques to innovate in protein drugs. For instance, Relay Therapeutics— a clinical-stage precision medicines company is increasing efforts to apply computational techniques to protein motion for drug delivery. As such, manufacturers are increasing R&D in techniques that bring down the cost of protein purification. This has helped manufacturers in the protein drugs market to develop protein-polymer therapeutics. Pharma companies are setting their collaboration wheels in motion to collaborate with think tanks and researchers from various universities.
There is a growing demand for homogenous therapeutic proteins. The ammonium sulfate precipitation method is considered as the gold standard for protein purification.