Oxycodone 20 mg extended release +1~9O9~545~6717oxycodone 10mg high @2060@[email protected] and Usage for Oxycodone Extended-Release Tablets
oxycodone 20 mg extended release TABLETS are indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate in:

Adults; and
Opioid-tolerant pediatric patients 11 years of age and older who are already receiving and tolerate a minimum daily opioid dose of at least 20 mg oxycodone orally or its equivalent.
Limitations of Use
Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations [see Warnings and Precautions (5.1)], reserve OXYCODONE HCl EXTENDEDRELEASE TABLETS for use in patients for whom alternative treatment options (e.g., nonopioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
oxycodone 20 mg extended release TABLETS are not indicated as an as-needed (prn) analgesic.
Oxycodone Extended-Release Tablets Dosage and Administration
Important Dosage and Administration Instructions
oxycodone 20 mg extended release TABLETS should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.
oxycodone 20 mg extended release TABLETS 60 mg and 80 mg tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are only for use in patients in whom tolerance to an opioid of comparable potency has been established. Adult patients who are opioid tolerant are those receiving, for one week or longer, at least 60 mg oral morphine per day, 25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone per day, 25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equianalgesic dose of another opioid.

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions (5.1)].
Initiate the dosing regimen for each patient individually; taking into account the patient’s severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see Warnings and Precautions (5.1)].
Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with OXYCODONE HCl EXTENDEDRELEASE TABLETS and adjust the dosage accordingly [see Warnings and Precautions (5.3)].
Instruct patients to swallow oxycodone 20 mg extended release TABLETS whole, one tablet at a time, with enough water to ensure complete swallowing immediately after placing in the mouth [see Patient Counseling Information (17)]. Instruct patients not to pre-soak, lick, or otherwise wet the tablet prior to placing in the mouth [see Warnings and Precautions (5.11)].
Cutting, breaking, crushing, chewing, or dissolving oxycodone 20 mg extended release TABLETS will result in uncontrolled delivery of oxycodone and can lead to overdose or death [see Warnings and Precautions (5.1)].
oxycodone 20 mg extended release TABLETS are administered orally every 12 hours.

Initial Dosage in Adults who are not Opioid-Tolerant
The starting dosage for patients who are not opioid tolerant is oxycodone 20 mg extended release TABLETS 10 mg orally every 12 hours.

Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression [ see Warnings and Precautions ( 5.3) ].

Conversion from Opioids to oxycodone 20 mg extended release TABLETS in Adults
Conversion from Other Oral Oxycodone Formulations to oxycodone 20 mg extended release TABLETS
If switching from other oral oxycodone formulations to oxycodone 20 mg extended release TABLETS, administer one half of the patient’s total daily oral oxycodone dose as oxycodone 20 mg extended release TABLETS every 12 hours.

Conversion from Other Opioids to oxycodone 20 mg extended release TABLETS
Discontinue all other around-the-clock opioid drugs when OXYCODONE HCl EXTENDEDRELEASE TABLETS therapy is initiated.
There are no established conversion ratios for conversion from other opioids to oxycodone 20 mg extended release TABLETS defined by clinical trials. Initiate dosing using oxycodone 20 mg extended release TABLETS 10 mg orally every 12 hours.

It is safer to underestimate a patient’s 24-hour oral oxycodone requirements and provide rescue medication (e.g., immediate-release opioid) than to overestimate the 24-hour oral oxycodone dosage and manage an adverse reaction due to an overdose. While useful tables of opioid equivalents are readily available, there is substantial inter-patient variability in the relative potency of different opioids.

Close observation and frequent titration are warranted until pain management is stable on the new opioid. Monitor patients for signs and symptoms of opioid withdrawal and for signs of oversedation/toxicity after converting patients to oxycodone 20 mg extended release TABLETS.

Conversion from Methadone to oxycodone 20 mg extended release TABLETS

Close monitoring is of particular importance when converting from methadone to other opioid agonists. The ratio between methadone and other opioid agonists may vary widely as a function of previous dose exposure. Methadone has a long half-life and can accumulate in the plasma.

Conversion from Transdermal Fentanyl to oxycodone 20 mg extended release TABLETS
Treatment with oxycodone 20 mg extended release TABLETS can be initiated after the transdermal fentanyl patch has been removed for at least 18 hours. Although there has been no systematic assessment of such conversion, start with a conservative conversion: substitute 10 mg of OXYCODONE HCI EXTENDED-RELEASE TABLETS every 12 hours for each 25 mcg per hour fentanyl transdermal patch. Follow the patient closely during conversion from transdermal fentanyl to oxycodone 20 mg extended release TABLETS, as there is limited documented experience with this conversion.

Initial Dosage in Pediatric Patients 11 Years and Older
The following dosing information is for use only in pediatric patients 11 years and older already receiving and tolerating opioids for at least five consecutive days. For the two days immediately preceding dosing with oxycodone 20 mg extended release TABLETS, patients must be taking a minimum of 20 mg per day of oxycodone or its equivalent. oxycodone 20 mg extended release TABLETS is not appropriate for use in pediatric patients requiring less than a 20 mg total daily dose. Table 1, based on clinical trial experience, displays the conversion factor when switching pediatric patients 11 years and older (under the conditions described above) from opioids to oxycodone 20 mg extended release TABLETS.