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Posted by seomypassion12 on September 8, 2024 at 2:22am 0 Comments 0 Likes
In the rapidly evolving world of technology and innovation, new concepts and terms frequently emerge, capturing the imagination of enthusiasts and experts alike. One such intriguing term is "ternatetoto." While "ternatetoto" might not yet be widely recognized, its potential implications and applications could be groundbreaking. This article delves into the possibilities and potential impact of ternatetoto,…
ContinuePosted by umair on September 8, 2024 at 2:19am 0 Comments 0 Likes
Molecular Origin of the Self-Assembly of Lanreotide into Nanotubes: A Mutational Approach
lanreotide powder, a synthetic, therapeutic octapeptide analog of somatostatin, self-assembles in water into perfectly hollow and monodisperse (24-nm wide) nanotubes. Lanreotide is a cyclic octapeptide that contains three aromatic residues. The molecular packing of the peptide in the walls of a nanotube has recently been characterized, indicating four hierarchical levels of organization. This is a fascinating example of spontaneous self-organization, very similar to the formation of the gas vesicle walls of Halobacterium halobium. However, this unique peptide self-assembly raises important questions about its molecular origin. We adopted a directed mutation approach to determine the molecular parameters driving the formation of such a remarkable peptide architecture. We have modified the conformation by opening the cycle and by changing the conformation of a Lys residue, and we have also mutated the aromatic side chains of the peptide. We show that three parameters are essential for the formation of lanreotide nanotubes: i), the specificity of two of the three aromatic side chains, ii), the spatial arrangement of the hydrophilic and hydrophobic residues, and iii), the aromatic side chain in the beta-turn of the molecule. When these molecular characteristics are modified, either the peptides lose their self-assembling capability or they form less-ordered architectures, such as amyloid fibers and curved lamellae. Thus we have determined key elements of the molecular origins of lanreotide nanotube formation.
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