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In placebo-controlled studies, 9% of peoples treated with sibutramine and 7% of peoples treated with placebo withdrew for adverse events.

Body as a whole: back pain, headache, flu syndrome, asthenia, injury accident, abdominal pain, neck pain, chest pain, and allergic reaction.

Cardiovascular system: vasodilation, tachycardia, migraine, hypertension, or increased blood pressure, palpitation.

Digestive system: Constipation, anorexia, increased appetite, dyspepsia, nausea, vomiting, gastritis, rectal disorder.

System: urinary tract infection, Dysmenorrhea, vaginal monilia, and metrorrhagia.

Other Adverse Events

Seizures

Convulsions have seemed as an adverse condition in three of 2068 peoples treated by sibutramine and in none of 884 people treated by placebo.
Interstitial Nephritis.

Postmarketing Reports

The voluntary effects of side effects temporally associated with the use of sibutramine are mentioned below. It is crucial to emphasize that although these conditions occurred during treatment with sibutramine, they may have no causal relationship with the medication. Weight reduction itself may be associated with an increased risk for some of these effects.

Hypersensitivity

Allergic hypersensitivity reactions ranging from mild urticaria and skin eruption to angioedema and anaphylaxis have been reported.

Other postmarketing Events

Cardiovascular system: congestive heart failure, atrial fibrillation, angina pectoris, heart arrest, decreased heart rate, supraventricular tachycardia, myocardial infarction, syncope, vascular headache, ventricular tachycardia, ventricular fibrillation.

Body as a whole: anaphylactoid reaction, chest tightness, chest pressure, anaphylactic shock, limb pain, sudden or unexpected death.

Digestive system: cholelithiasis, cholecystitis, duodenal ulcers, gastrointestinal bleeding, intestinal obstruction, increased salivation, stomach ulcers, mouth ulcers, and tongue edema.

Special senses: blurred vision, abdominal vision, dry eye, increased intraocular pressure, otitis media, otitis external, tinnitus, photosensitivity.

Respiratory system: nasal congestion, epistaxis, respiratory disorder, skin and appendages alopecia, photosensitivity.

Abuse and Physical and Psychological Dependence Medical experts should carefully evaluate individuals for a history of drug abuse and follow them carefully, observing them for signs of damage or misuse.

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