Global Immune Repertoire Sequencing Market: Introduction

Immune repertoire is the sum of T cell receptors and B cell receptors that make an organism's adaptive immune system. It is extensively used in biomarker discovery to improve the success rate and cost-effectiveness of rational drug development.

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Advancements in next generation sequencing (NGS) have facilitated the development of a prevailing new technology known as immune repertoire sequencing for probing the complimentary determining region of these receptors. Immune repertoire sequencing targets T and B-lymphocytes and utilizes the 5’ Rapid Amplification of cDNA Ends (RACE) Technology.

Global Immune Repertoire Sequencing Market: Trends, Drivers, Restraints

Increase in government support for pharmacogenomics-based drug recovery is the major driver of the global immune repertoire sequencing market. Additionally, rapid rise in numerous therapeutic areas such as infectious diseases, cardiology, oncology, and pain management boosts the growth of the global market.

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Agreements & partnerships among manufacturers is another key factor projected to contribute to the growth of the global immune repertoire sequencing market during the forecast period. For instance, in March 2018, ArcherDX and Ambry Genetics announced a partnership agreement to develop promising and innovative immunotherapies.

Increase in demand for personalized medicine is expected to propel the global immune repertoire sequencing market in the next few years, as personalized medicine uses an individual’s genetic makeup to direct the decisions made about the prevention, diagnosis, and cure of diseases.

Launch of novel products by key players and advancements in research & development are likely to fuel the growth of the global immune repertoire sequencing market in the near future. In 2017, ArcherDX launched Archer Immunoverse B Cell Receptor (BCR) assays to characterize the human B cell repertoire.

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According to a study published by Cold Spring Harbor Laboratory in 2017, researchers from the Stanford University applied immune repertoire sequencing to identify disease-related signatures in the immune systems of patients with systemic sclerosis-related pulmonary hypertension, which is a rare chronic autoimmune disease that affects the connective tissue. Hence, increase in research on immune repertoire sequencing is projected to augment the global immune repertoire sequencing market.

However, distinctive biological variations from the errors and the bias introduced in various different steps act as major restraints of the global immune repertoire sequencing market. Moreover, differences of data generation and processing in different laboratories are anticipated to hamper the growth of the global immune repertoire sequencing market during the forecast period.

COVID -19 Impact on Global Immune Repertoire Sequencing Market

The COVID-19 pandemic has had a significant effect on the global immune repertoire sequencing market due to undermining clinical trials, inadequate supply chain management & raw material storage, and patient incompliance. Moreover, decline in funding by governments due to the pandemic has negatively affected the global immune repertoire sequencing market.

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North America to Dominate Global Immune Repertoire Sequencing Market

In terms of region, North America is expected to dominate the global immune repertoire sequencing marked during the forecast period. The U.S. is likely to dominate the market in the region due to increase in demand for immunotherapy for cancer and other infectious diseases.

Europe was the second largest market for immune repertoire sequencing in 2020 due to funding by governments and increase in health care expenditure

The market in Asia Pacific, primarily in Japan and China, is projected to witness significant growth due to international collaborations for immune repertoire sequencing and developments.

However, Middle East & Africa is expected to be the least attractive market for immune repertoire sequencing due to lack of skilled personnel and Internet access limitations for data analysis

Key players in the global immune repertoire sequencing market are:

• Adaptive Biotechnologies
• Thermo Fisher Scientific
• Pacific Biosciences
• Illumina, Inc.
• Juno Therapeutics
• Hoffmann La-Roche AG
• CD Genomics
• QIAGEN N.V.
• Atreca, Inc.
• Oxford Nanopore Technologies, Ltd.
• ArcherDX, Inc.
• Abvitro (Now Juno Therapeutics)
• Agilent Technologies
• Irepertoire, Inc.
• Takara Bio, Inc.
• Others

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