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We can therefore use this dataset to determine if there is any role for 5 reductase inhibitors in the treatment of asymptomatic men with enlarged prostates.MethodsThe REDUCE study was designed to assess the efficacy of dutasteride in decreasing the incidence of biopsy detected prostate cancer over a four year period in men at increased risk of prostate cancer.

The impact was assessed both in terms of the percentage change in the treatment effect estimate and the change in the statistical significance of the treatment effect estimate after adjustment.ResultsAssessments of systematic reviewsThe Cochrane Library published 309 new reviews in Issue 4, 2006, Issue 1, 2007, and Issue 2, 2007 (fig 1).

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