Global Synthetic siRNA Market is expected to reach $xx Mn in 2026 from $xx Mn in 2019, at a CAGR of xx% during forecast period.
Global Synthetic siRNA Market: Overview

Synthetic siRNA are also known as short interfering RNA, which is a type of non-coding double stranded RNA of 20-23 nucleotide base pairs in length. It is a powerful tool used for modulating gene expression by RNA interference (RNAi).siRNAs consist of two RNA strands, an antisense (or guide) strand and a sense (or passenger) strand, which form a duplex 19 to 25 bp in length with 3' dinucleotide overhangs. siRNA are transfected into cells by using delivery methods like polymer-based transfection reagents, electroporation or by adding chemical modifications.
Global Synthetic siRNA Market Dynamics

Increasing applications in gene therapy is the major factor driving the market.

Gene therapy offers a promising therapeutic platform as it targets disease-causing genes in a sequence-specific manner, which enables more precise and personalized treatment of diverse life-threatening diseases. Global prevalence of chronic diseases like cancer is noticing increasing number of applications in molecular diagnostics and incorporation of RNAi techniques in personalized medicines. Other advantages of siRNA include the high efficiency of the gene knockdown, the ability to easily target the gene of interest, as well as stable and long-term silencing by expressing shRNAs are accelerating the market growth.

However, many challenges related to siRNA may limit the market growth. One of the biggest challenge to siRNA based therapeutics is its intracellular delivery, as it has weak stability and pharmacokinetic behavior. It also faces problem of off-targeting during delivery since genes are read in both directions, there exists a possibility that even if the intended antisense siRNA strand is read and knocks out the target mRNA, the sense siRNA strand may target another protein involved in another function. In recent years, there has been a decline in FDA drug approval rates. Getting FDA approval for a new drug has become extremely challenging. It approved less than half the number of new drugs in 2016 (19 so far) when compared to 2015 (45 total).Along with this, high cost of synthesis of required siRNA may hamper the market growth.

The report has profiled key players in the market from different regions. However, the report has considered all market leaders, followers, and new entrants with investors while analyzing the market and estimation the size of the same. Increasing R&D activities in each region are different and focus is given on the regional impact on the cost, availability of advanced technology are analyzed.
Global Synthetic siRNA Market Segment Analysis:

The Global Synthetic siRNA Market is segmented based on the tools and applications.

Based on applications, the oncology segment is expected to hold larger market share of XX% in 2019. According to the WHO, cancer is the second leading cause of death globally. Approximately 70% of deaths from cancer occur in low- and middle-income countries. Cancer-causing infections, such as hepatitis and human papillomavirus (HPV), are responsible for approximately 30% of cancer cases in low- and lower-middle-income countries. High-risk human papillomaviruses infect skin and mucosa, causing approximately 5% of cancers worldwide. The selected siRNA prevents the tumor from growing via RNAi to decrease expression of the M2 subunit of R2 (ribonucleotide reductase).

Global Synthetic siRNA Market1

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Global Synthetic siRNA Market Regional Insights:

Regional Insights

North America dominates the global market and is expected to continue the dominance throughout the forecast period.

The US leads the global market owing to huge number of RNAi therapeutics in the development stage. High investments from biotechnology companies for the development of novel therapeutics is contributing to the market growth in the region. Rising prevalence of personalized medicines for life threatening diseases like cancer, HIV drives the demand for Synthetic siRNA market. For instance, AstraZeneca's agreement with Ionis pharmaceuticals is one of the big deals that are investing heavily into RNA-interference technology. According to the news released on 10th August 2018, the US Food and Drug Administration approved Onpattro (patisiran) infusion for the treatment of polyneuropathy. Recently, the FDA-approved GIVLAARI (givosiran, ALN-AS1) for the treatment of adults with acute hepatic porphyria (AHP).

The report also helps in understanding Global Synthetic siRNA Market dynamics, structure by analyzing the market segments and project the Global Synthetic siRNA Market size. Clear representation of competitive analysis of key players by product, price, financial position, product portfolio, growth strategies, and regional presence in the Global Synthetic siRNA Market make the report investor’s guide.
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Global Synthetic siRNA Market2
Global Synthetic siRNA Market, by Region:

• North America
• Europe
• South America
• MEA
• APAC
Key players operating in Global Synthetic siRNA Market:

• Thermo Fisher Scientific Inc.
• Bioneer
• Dharmacon (ThermoFisher)
• Invitrogen
• Integrated DNA Technologies
• MWG Biotech
• OligoEngine
• Proligo (Sigma)
• Qiagen
• AstraZeneca
• Ionis pharmaceuticals
• Alnylam Pharmaceuticals
• Arcturus Therapeutics
• Dicerna Pharmaceuticals
• Merck & Co. Inc. (Sigma Aldrich)
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