E-cig use has skyrocketed

In the United States, cardiovascular disease is responsible for about one-third of smoking-associated deaths in smokers, and secondhand smoke causes approximately 34,000 early deaths from heart disease each year in nonsmokers. Endothelial cells line the interior surface of blood vessels and play a critical role in heart and cardiovascular health. Although some studies have suggested that Ecig Wholesale deliver lower levels of carcinogens to users than do conventional cigarettes — perhaps decreasing the risk of cancer — the effect of e-cigarette use on vascular health has been unclear.

Despite these uncertainties, the use of e-cigarettes has skyrocketed since their introduction about a decade ago, particularly among young people. The Food and Drug Administration estimated that more than 3.5 million middle and high school students used e-cigarettes in 2018, though sales to minors are prohibited. In 2018, the FDA restricted the sale of flavored e-cigarettes to adults-only venues, with the exception of tobacco, menthol and mint flavors, which can be sold wherever traditional cigarettes are sold.

“One in five high school students have tried e-cigarettes, perhaps because they feel they are relatively safe,” Lee said. “But we found the e-liquids caused changes in the endothelial cells that are closely related to those seen during the development of cardiovascular disease.
The researchers investigated the effect of six different popular e-liquid flavors — fruit, tobacco, sweet tobacco with caramel and vanilla, sweet butterscotch, cinnamon, and menthol — with nicotine levels of 0, 6, and 18 milligrams per milliliter on endothelial cells derived from human iPS cells. They found that while several of the liquids were moderately toxic to the endothelial cells, the cinnamon- and menthol-flavored e-liquids significantly decreased the viability of the cells in culture even in the absence of nicotine.
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