Compound 7P powder (1890208-58-8)


Raw Compound 7P powder which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, Raw Compound 7P powder was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of Raw Compound 7P powder translates into stimulation of axon regeneration in vivo.Compound 7P powder

Raw Compound 7P powder which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina.

In an animal model of optic nerve injury, Raw Compound 7P was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of Raw Compound 7P translates into stimulation of axon regeneration in vivo.
Compound 7p was developed as one in series of compounds with the aim of identifying dual-acting thromboxane receptor antagonist/synthase inhibitors .

In fact compound 7p shows selectivity for prostaglandin I2 synthase (PTGIS , CYP8A1) over thromboxane synthase (CYP5A1) .
Raw Compound 7P (2-[(2-methoxyphenyl)[(4-methyl phenyl) sulfonyl] amino]-N-(4-methoxy-3-pyridinyl) acetamide) powder which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, Raw Compound 7P powder was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of Raw Compound 7P powder translates into stimulation of axon regeneration in vivo.further optimization of Raw Compound 7P powder and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.

Compound 7p (2-[(2-methoxyphenyl)[(4-methyl phenyl) sulfonyl] amino]-N-(4-methoxy-3-pyridinyl) acetamide) showed the highest activity against cervical cancer cells. In a nude mouse xenograft model inoculated with HeLa cells, 7p showed dose-dependent inhibition of cervical tumour growth. Histopathological examination of excised tumour-bearing tissues showed that 7p improved the microstructure in a dose-dependent manner. Compound 7p also increased the proportions of HeLa cells in G0/G1 and S-phase and significantly decreased that of G2/M-phase. The effects of 7p on C-caspase-3, C-caspase-9, Bcl-2 and Bax expression in HeLa cells were also determined.