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INTRODUCTION

Liposomes, Lipid Nanoparticles (LNPs), and other lipid-based formulations have been clinically proven to improve the therapeutic index of a wide variety of active pharmaceutical ingredients (API). Lipids are an amphipathic class of biological molecules that exhibit ideal safety and pharmacokinetic profiles when…

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Liposomes have long been established as an effective drug delivery vehicle for API with poor pharmacokinetics, limited bioavailability or solubility, and high toxicity. Discovered in the 1960s by Alec D. Bangham, liposomes were originally utilized as an artificial bilayer to study membranes’ biophysical properties. The liposome morphology can be described as an aqueous core surrounded by one or many lipid bilayers, a lipid phase preferred by cylindrical space-filling lipid molecules. The…

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