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November 2019 Blog Posts (49,662)
First-in-human trial of senolytic drugs encouraging
First-in-human trial of senolytic drugs encouraging
Senolytics target cellular senescence, a process in which damaged cells, rather than dying, persist and become toxic to cells around them. Cellular senescence has been shown to drive multiple age-related diseases, including idiopathic pulmonary fibrosis (IPF), a chronic, irreversible and progressive disease that results in scarring of the lungs. In animal studies, run by Mayo Clinic collaborators James Kirkland, M.D., Ph.D.; Nathan…
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Nanoparticles Enhance Quercetin to Selectively Destroy Senescent Cells
Nanoparticles Enhance Quercetin to Selectively Destroy Senescent Cells
Researchers have demonstrated that nanoparticles coated with quercetin molecules can selectively target and eliminate harmful senescent cells.
As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby healthy cells to…
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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age
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NAD+ availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ biosynthesis and ameliorate various pathologies in mouse disease models. In this study, we conducted a 12-month-long NMN administration to regular chow-fed wild-type C57BL/6N mice during their normal aging. Orally administered NMN was quickly utilized to…
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