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A combination comprising a topoisomerase inhibitor and an anti-Trop-2 antibody, sacituzumab govitecan-hziy comprises the following three elements: the topoisomerase inhibitor SN-38; the humanized monoclonal antibody, hRS7 IgG1 (also known as sacituzumab), which binds to Trop-2; and • a hydrolysable linker (named CL2A), which connects the humanized monoclonal antibody to SN-38. Recombinant monoclonal antibodies are made by mammalian (murine myeloma) cells, whereas SN-38 and CL2A are made by…

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RETEVMO must be taken orally twice daily, approximately every 12 hours until any disease progression or unacceptable toxicity is seen. This drug may be taken with or without food unless coadministered with a proton pump inhibitor. It is noted that RETEVMO capsules should not be crushed and chewed; they must be administered orally. If any dose is missed, only take it if at least 6 hours are left for the next…

Apart from 180 mg vial, it also comes as TRODELVY 200 mg in single-dose vials for reconstitution. It is given by dripping in the vein as the first and subsequent infusion. During and at least after 30 minutes of infusion, the patient must be monitored and observed for any post-infusion changes. The first infusion lasts for 3 hours, and in subsequent infusions, TRODELVY is infused for 1-2 hours. It…